Associate Director – ADC Conjugation

Associate Director – ADC Conjugation

Gaithersburg, MD

As an Associate Director specializing in ADC Conjugation, you will be part of a team of highly skilled and passionate individuals responsible for innovating and generating best-in-class antibody-drug conjugates (ADCs) for the Oncology therapeutic area. This exciting opportunity allows you to lead and contribute to fast-paced, multi-disciplinary drug development efforts.

Accountabilities

• Team Leadership: Manage and mentor a team of conjugation scientists to deliver platform and pipeline-focused drug conjugates for oncology and other therapeutic areas.
• Workflow Coordination: Coordinate, align, and plan conjugation and analytical workflows within a larger team.
• Method Development: Develop and optimize novel conjugation methodologies to improve ADC properties.
• Collaboration: Work collaboratively with a diverse group of scientists across various therapeutic areas, chemistry, and process development to ensure timely progress in research projects and drive technological innovations.
• Laboratory Maintenance: Lead and coordinate laboratory maintenance, including equipment upkeep and lab safety.

Essential Skills/Experience

• Ph.D. in Organic Chemistry, Chemical Biology, Biochemistry, or other relevant disciplines with 7+ years of relevant industrial experience or Masters in Organic Chemistry, Chemical Biology, Biochemistry, or other relevant disciplines with 12+ years of relevant industrial experience
• ADC Design: Demonstrated hands-on experience in the design and generation of antibody-drug conjugates.
• Analytical Techniques: Working knowledge of characterization using analytical techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography–Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC.
• Protein Purification: Hands-on experience and knowledge of protein purification using HIC, IEX, SEC, and affinity chromatography. Experience with GE AKTA FPLC is preferred.
• Project Management: Proven ability to work independently, effectively plan and organize work activities, and prioritize task completion to meet project deadlines.
• Problem-Solving: Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset and maintaining a detailed laboratory notebook.
• Scientific Innovation: Track record of scientific innovation as evidenced by scientific publications, patents, and oral presentations at conferences.
• Communication Skills: Excellent written and verbal communication skills and the ability to effectively present complex scientific data to cross-functional teams and senior management.

Desirable Skills/Experience

• Mass Spectrometry: Strong knowledge in mass spectrometry and other novel analytical techniques for comprehensive assessment of bioconjugates.
• CRO Coordination: Experience working and coordinating with Contract Research Organizations (CROs)
• People Management: Experience managing a team of bioconjugation and analytical chemists

At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. Our collaborative environment brings together the best minds from academia and industry to share knowledge, grow together, and build meaningful careers. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs. We are committed to scientific innovation, taking smart risks, challenging the norm, and learning from failures. Our global cross-functional team applies new knowledge and diverse perspectives to keep learning and make a meaningful difference for patients worldwide.

About Our Gaithersburg Oncology Hub

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

So, what’s next?

Join us at AstraZeneca and make a meaningful difference for patients around the world!

If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: December 16, 2024

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more-

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

The annual base pay (or hourly rate of compensation) for this position ranges from $128,631 to $192,946. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.