Data Scientist

Key Responsibilities

• Lead bioinformatic and data science efforts focused on single‑cell RNA‑seq (scRNA‑seq) data, including experimental design support, data processing, quality control, and downstream analysis.
• Apply advanced statistical, machine learning, and AI methods to single‑cell transcriptomic data to identify cell states, trajectories, biomarkers, and mechanistic insights relevant to clinical outcomes.
• Integrate scRNA‑seq data with complementary data types (e.g., bulk RNA‑seq, genomics, clinical metadata) to support translational and clinical decision‑making.
• Analyze and interpret single‑cell TCR sequencing (scTCR‑seq) data to characterize T‑cell clonality, diversity, and clonal dynamics in clinical cell therapy studies.
• Integrate scRNA‑seq and scTCR‑seq data to link T‑cell receptor repertoire features with transcriptional states, phenotypes, and clinical outcomes.
• Design and implement custom analytical tools and models tailored to cell therapy and immunology research questions.
• Collaborate closely with biologists, clinicians, and cross‑functional teams to translate single‑cell analytics into actionable insights for ongoing clinical programs.
• Contribute to the development of analytical models for clinical NGS and single‑cell data in regulated environments.
• Establish and maintain reproducible, scalable data architectures using cloud platforms and/or high‑performance computing resources.
• Build and manage code repositories, documentation, and best practices for single‑cell data analysis.
• Communicate complex analytical methods and findings through clear reports, visualizations, presentations, and collaborative discussions.
• Stay current with emerging single‑cell technologies, methods, and tools, and proactively incorporate them to improve analytical approaches.

Essential Qualifications, Skills and Experience

Education & Experience

• 5+ years of relevant experience with a BS/BA,  
• or 3+ years with an MS/MA,  
• or 1+ year with a PhD  
•   in data science, computational biology, bioengineering, or a related field, with relevant post‑graduate experience.

Technical & Scientific Expertise

• Deep hands‑on experience with single‑cell RNA‑seq data analysis, including normalization, batch correction, clustering, annotation, trajectory inference, and differential expression.  
• Strong background in NGS workflows, with emphasis on single‑cell experimental platforms and data characteristics.  
• Proficiency with single‑cell immune repertoire sequencing concepts, including clonotype definition, diversity metrics, and longitudinal clonal tracking.  
• Expertise in bioinformatics and computational biology tools and frameworks commonly used for scRNA‑seq and scTCR‑seq analysis.  
• Proficiency in Python and R, including development of reproducible analytical pipelines, workflows, and visualizations.  
• Experience working with cloud computing platforms and/or high‑performance computing clusters.  
• Solid understanding of statistical methods and their application to single‑cell and biomedical data.

Domain Experience

• Experience in immunology, immune‑oncology, or cell therapy research is a strong plus.
• Ways of Working & Behaviors
• Team‑oriented mindset with the ability to work independently in a fast‑paced, collaborative environment.  
• Strong communication skills, with the ability to explain complex analytical concepts to non‑experts.  
• Flexibility to adjust priorities and contribute beyond the initial scope as project needs evolve.
  

Date Posted

20-abr-2026

Closing Date

17-may-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.