Associate Principal Physician Scientist, Genomics

Associate Principal Physician Scientist, Genomics

Hybrid model of work: 3 days in office, 2 remote per week

Competitive Salary & Benefits

Make a more meaningful impact to patients’ lives around the globe

Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

With our ground-breaking pipeline, the outlook is bright. Be proud to be part of a place that has achieved so much, yet is still moving forward. There’s no better time to join our global, growing enterprise as we lead the way for healthcare and society.

What You’ll do

AstraZeneca's Centre for Genomics Research (CGR) is currently seeking a physician with a research background to join our dedicated team focused on the company-wide Genomics Initiative which includes the analysis of up to 2 million genomes. In this role, you will apply your medical knowledge to help interpret DNA and multi-omics research data from AstraZeneca's clinical trials and broad biobanks representing ancestry diverse populations. Furthermore, you will play a pivotal role in leading deep-phenotyping and cohort stratification efforts aimed to further improve opportunities of identifying and validating new therapeutic targets for drug development. You will also contribute to the harmonization of healthcare records collected from a diverse range of geographical regions, an essential activity for maintaining data consistency and reliability in our research efforts.

The successful candidate will work with leaders in human genomics delivering innovative science to genome analytics. You will also work closely with experts in translational science, drug discovery, pre-clinical modelling, and clinical development; thus, contributing to the broader objectives and success of the company-wide Genomics Initiative. This unique role requires an individual who is innovative, passionate about science, and can generate and lead original projects in a global R&D environment. The role will be primarily office-based, with some national and/or international travel to support projects, participate in team development meetings and attend conferences.

What you will be doing on daily basis? You will be…

• Coordinating analyses within AstraZeneca’s Centre for Genomics Research
• Applying innovative quantitative genomic analyses to large-scale cohort studies to identify clinically relevant disease and response loci
• Deliver novel insights into the biology of disease, validation of new targets for medicines and the improvement of selection of patients for clinical trials
• Providing detailed reports regarding the study design, analysis approach and research findings and presenting to study teams
• Champion and lead the strategic direction of own projects and initiatives.
• Seek and apply best practices in processes, data analysis, and decision-making in leading project teams in a virtual environment
• Contribute to the overall success of the wider AstraZeneca BioPharmaceuticals R&D functions.
• Ensuring own work, and work of team, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other internal AstraZeneca standards and external regulations

Qualifications, Skills and Experience Required:

Essential:

• Degree in Medicine
• PhD degree (or equivalent experience)
• Experience in large-scale data analysis
• Ability to communicate effectively with team members and non-experts, both verbally and through documentation
• High level understanding or interest in the potential of genomics to impact drug discovery
• In-depth understanding of medicine in its broadest context
• Desire and willingness to ‘Follow the Science’ beyond core disease area of expertise
• Ability to carry out duties under minimal supervision
• Excellent interpersonal skills and willingness to work within a team in a quickly evolving environment
• Track record of peer-reviewed publications in high-level scientific journals

Desirable:

• Previous experience in a similar role
• Experience harmonising clinical phenotype information and diverse health datasets  
• Pragmatic experience with data querying and data exploration tools
• Experience in case-control sequencing based statistical analyses
• Experience quantifying and interpreting the clinical relevance of rare variants
• Familiarity working on genomics studies involving one of AstraZeneca’s core therapeutic areas (see: https://www.astrazeneca.com/our-therapy-areas.html)
• Clinical experience, now seeking entry to the biotech/pharmaceutical industry

Why AstraZeneca?

Make a more meaningful impact to patients’ lives around the globe

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Where can I find out more?

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.