Senior Scientist

Senior Scientist 

Do you have a passion for Bioanalysis (BA), ADME and DMPK science, applied to Cancer biology?  Join AstraZeneca Oncology DMPK and help turn science into life-changing medicines for patients.

About AstraZeneca

AstraZeneca is a global biopharmaceutical company united by a bold ambition: to redefine cancer and restore patients’ lives. Oncology R&D is a major growth engine, with a diverse pipeline across all stages of development. We collaborate across disciplines to solve complex problems and bring the next generation of cancer therapies to patients. 

About The Site

Our Waltham campus is a modern, collaborative environment with cutting-edge technology and more than 800 scientists and professionals. It is a short drive from Boston and designed to foster teamwork and cross functional science. As part of our commitment to patients and scientific excellence, we plan to relocate to Kendall Square/Cambridge in 2026, expanding our access to the world class biotech ecosystem. 

Business Area

AstraZeneca Oncology is one of the fastest growing teams in the industry. We deliver value through scientific excellence, launch readiness, and lifecycle maximization, changing the practice of medicine through our marketed portfolio and innovative pipeline.

The Oncology DMPK department provides integrated support across the portfolio—bioanalysis (BA), ADME, and translational PK/PD modeling and simulation. We partner closely with discovery and development teams to generate high quality data that informs candidate selection and accelerates decision making.

Role Summary

We are seeking a Senior Scientist to join our ADME group in Waltham, reporting to the Director of DMPK. In this role, you will deliver BA and ADME support to Oncology discovery programs and contribute to the quantitative analysis of in vivo PK/PD studies across our global portfolio. You will collaborate with established ADME teams in Boston (US) and Cambridge (UK) and present findings in multidisciplinary settings.

What you will do

• Independently develop and validate bioanalytical methods, analyze biological samples using quantitative LC-MS/MS assays, analyse and present findings back to project teams.

• Lead quality control and data review for BA to ensure accuracy, reproducibility, and regulatory readiness where applicable.

• Conduct operation, maintenance, and troubleshooting of key platforms: laboratory automation/liquid handling, mass spectrometers and LC equipment such as Hamilton liquid handling system, AB Sciex triple quadrupoles, HRMS and Shimadzu LC

• Develop and implement state-of-the-art technologies in the field of drug metabolism.

• Support the department’s leadership team in both the strategic vision for the department and in the efficient and progressive running of the department. 

• Ensure compliance with Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations.

Essential Requirements

• BS/MS (or equivalent) in pharmaceutical sciences, chemistry, biochemistry, or related discipline, with 4+ years of industry experience.

• A solid foundation in bioanalytical chemistry, with demonstrated expertise in LC‑MS/MS, including method development and quantitative analysis. 

• Hands-on experience with the operating, maintaining, and troubleshooting mass spectrometers and LC equipment; familiarity with laboratory automation/liquid handling and experience evaluating and implementing new bioanalytical technologies. 

• Experience conducting in vitro mechanistic studies to address ADME-related challenges is a plus.

• Excellent problem-solving, organization, documentation, and communication skills; ability to thrive in a collaborative, multidisciplinary, fast‑paced environment.

Why AstraZeneca?

At AstraZeneca, you’re empowered to push the boundaries of science in an inclusive culture that champions diversity, collaboration, and lifelong learning. There’s no better place to make a meaningful impact on medicine, patients, and society—and to develop your career beyond what you thought possible.

So, what’s next?

If you’re excited by the opportunity to shape the future of oncology medicines, we want to hear from you. Apply today—and if you know someone who would be great fit, please share this opportunity. 

Where can I find out more?

Our social media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

The annual base pay (or hourly rate of compensation) for this position ranges from $109,912.80 to $164,869.20. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans

Date Posted

23-Feb-2026

Closing Date

08-Mar-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.