Senior Scientist/Associate Director, Translational PKPD

Job Title: Senior Scientist/Associate Director, Translational PKPD

Location: Waltham, MA/ Boston, MA

Do you have expertise in Oncology, and a passion for PKPD modeling and DMPK science, applied to Cancer biology? Would you like to apply your expertise to impact the lives of patients in a company that follows the science and turns ideas into life changing medicines?

As a Senior Scientist/Associate Director in Translational PKPD, you will have the opportunity to drive strategy and provide global leadership in DMPK science on Antibody Drug Conjugates (ADCs), Radioconjugates (RCs) large molecules. Your role will involve providing projects with DMPK support, exploring the PK/PD/Efficacy relationships in pre-clinical models, using these models to build a quantitative understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.

Essential for the role:

• Representing the Translational PKPD group and providing overall scientific leadership for cross functional and external collaborations involving DMPK.

• Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP).

• Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials.

• Driving learnings through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing.

• Leading and participating in Oncology strategic scientific initiatives and continuous improvement projects by providing expert DMPK knowledge and participating in the development of Discovery or Development strategies in PKPD.

• Working collaboratively and in continuity with other partner functions.

• Having a breadth of influence and impact across AstraZeneca Clinical Pharmacology and externally within their discipline.
  

Minimum Requirements:

• PhD in a discipline with a significant component of analysis and quantitation, such as pharmaceutical sciences, quantitative pharmacology, pharmacometrics, engineering, physics, or applied mathematics.

• • Minimum 4 years of relevant industry experience in DMPK/preclinical/translational project-facing role within pharmaceutical R&D.

• • Excellent interpersonal and communication skills coupled with strong influence and leadership skills.

• Specialist in tools such as WinNonLin/Phoenix NLME, R, SimCYP , NonMem, Berkeley Madonna and MATLAB.

• Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to prespecified quality and cost.

• Track record of demonstrating strong publication record demonstrating comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development
  

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Ready to make an impact? Apply now and join us on this exciting journey!

The annual base pay (or hourly rate of compensation) for this position ranges from $135,457.60 - $203,186.40 USD Annual for the Associate Director role or $116,670.40 - 175,005.60 USD Annual for the Senior Scientist role. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Compensation Pay Range:

135,457.60 - 203,186.40 USD Annual

The annual base pay (or hourly rate of compensation) for this position is outlined above. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

08-Jan-2026

Closing Date

08-Jan-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.