Senior Research Scientist, Chemical Biology & Proteomics
We areseekingahighly motivatedandtalentedscientist to join ourChemicalBiology & Proteomics(CBP)teamat AstraZeneca in Waltham, MA.As aSenior Research Scientist, youwill be an integral member of a team generating pre-clinical pharmacology data to understandefficacyand selectivityof therapeutic agents. You will have the opportunity to work witha team ofcross-functionalscientists and support the development of new and successful therapiesfor patients.Ifyou’reinspired by the possibilities of science to make a difference and ready to discover what you can do – join us.
KeyResponsibilities
Develop andemploychemicaltoolsandproteomicstechnologies toprovideimpactfulmechanisticinsightsfordrug discoveryprojectsacrosstherapeutic areas
Develop mass spectrometry-based methodsto conductcovalentscreens
Design and execute experimental plans to understandtarget engagementandselectivityprofilesof therapeutic agents,understand drug-induced proteomedynamicsand investigatepost-translational modifications (PTM)
Represent CBP team, and communicate withprojectdiscipline leads, andcontribute togeneration ofmechanistic hypothesisthroughinterpretation of sophisticated proteomics data
Maintainand troubleshootLC-MSsystem
Essential Requirements
PhD with2+ yearsof post-doctoral/industrialexperience
Knowledge and hands-on experience with sample preparation and method development on quantitative mass spectrometry (relative and/orabsoluteproteinquantification)
Experience with mass spectrometry-based covalent screening, and provenexpertisewith IP-MS or chemical probe-basedenrichment MSworkflows,andexperiencedeveloping automated processes to analyzelarge numberof samplesforMS analysis
Skilled ininvestigatingcompound effectsunder biochemical and cellular settingswith quantitativemass spectrometry,e.g.PTMs, protein complexes perturbations,etc
Experience indeterminingprotein abundanceand turnoverby using quantitative proteomicstechnologies, such as TMT, SILAC,and/orlabel-free approaches and data independent acquisition (DIA)
Expertisein data analysis and an ability to communicate data interpretation clearly
Significant external reputation gained through professional recognition, externalpresentationsand publicationsin high-impact journals
Ability to contribute with a positive, result oriented andproblem-solving attitude
Desirable Requirements
Experience in pre-clinical drug discovery
Experience usingThermoQ-Exactive,OrbitrapExploris,Eclipse,AstralZoomorTimsTOF
ExperiencewithXcalibur, Proteome Discoverer,MaxQuant, Skyline,Spectronautand DB search engine tools
Experience with liquid handling systems and robotic automation
Familiarity with targeted proteomics is a plus
Why AstraZeneca?
At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There is no better place tomake a difference to medicine,patientsand society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning,growthand development.
Next Steps – Apply today!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feelwell qualifiedfor this opportunity. If you know someone who would be a great fit, please share thispostingwith them.
The annual base pay for this position ranges from $116,284.00 - $174,426.00 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles).
Date Posted
09-Apr-2026Closing Date
29-Apr-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
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