Senior Principal Scientist

This position provides scientific leadership for Early Chemical Development in the US. The role focuses on establishing relationships with and supporting Oncology Discovery Chemistry (and partner departments) to facilitate the smooth transition of projects to Development. Additionally, the individual will build new scientific collaborations in the Boston area to develop Pharmaceutical Sciences’ capability in Kendal Square. Support is also expected for Isotope Chemistry within Early Chemical Development, providing global expertise and local support for RIC (Radioimmune Conjugate) projects. The individual will have extensive knowledge of drug discovery and clinical drug development (including labelled substances) as well as experience in establishing and developing collaborations in new scientific and technical areas.

Accountabilities

• Ensure connectivity between Discovery functions in Boston and Early Chemical Development to allow smooth transition of projects from Discovery to Development.
• Work across the Boston scientific and technological landscape to develop new partnerships and collaborations supporting Pharmaceutical Sciences activities.
• Provide expertise in Isotope Chemistry to Early Chemical Development.
• Support Early Chemical Development projects at external CDMOs (Contract Development and Manufacturing Organisations) with a focus on Isotope Chemistry.
• Provide expert support in the US to AstraZeneca RIC projects as required.
• Provide departmental scientific leadership globally for Early Chemical Development and locally for Pharmaceutical Sciences in Boston.

Essential Skills/Experience

• Broad specialist knowledge of organic synthesis, including expertise in Isotope Chemistry.
• Extensive experience in Drug Discovery and Development, with detailed understanding of application of Process Chemistry, Isotope Chemistry, and Analytical Chemistry.
• Experience working with CDMOs (including to cGMP) to deliver projects.
• The individual should also have an extensive track record of establishing collaborations with external parties to drive scientific innovation. This should be supported by a world-class publication record.

When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and daring world.

At AstraZeneca, we are dedicated to following the science and pioneering new frontiers. Our team is committed to eliminating cancer as a cause of death, uniting us with a shared vision. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we continuously push forward, fusing pioneering science with the latest technology to achieve breakthroughs. Backed by investment, we aim to deliver six new molecular entities by 2025. Our collaborative research environment has built an unrivalled scientific community, expediting research in some of the hardest-to-treat cancers. Join us and build a rewarding career as part of a team committed to improving the lives of millions with cancer.

Ready to make a difference? Apply now and join us on this exciting journey!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.