Senior Biotransformation Scientist

Are you a highly motivated biotransformation scientist with experience in metabolite identification using mass spectrometry? Would you like to apply your expertise in a company that is accelerating innovative science and turning ideas into life-changing medicines? Join us to be part of the development of future treatments for Cardiovascular, Renal, and Metabolic diseases!

Working at AstraZeneca means being entrepreneurial, thinking big, and working together to make the impossible a reality. We are now recruiting a highly skilled and motivated biotransformation scientist to join the DMPK Drug Design and Biotransformation team within the Early Cardiovascular, Renal, and Metabolism (CVRM) therapeutic area at AstraZeneca. The position is based at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden

Accountabilities

As a Senior Biotransformation Scientist, you will be part of a strong team at the forefront of DMPK science focusing on the biological fate of drug molecules in preclinical species and humans. This is a lab-based role, where you will study and elucidate mechanisms and pathways that determine the metabolism and disposition of drug substances. You are responsible for the identification of drug metabolites in biological samples and will provide significant input from target identification to life-cycle management.

In this role, you will work in a team environment to support programs through the conduct of drug metabolism studies designed to understand biotransformation pathways and routes of elimination of diverse therapeutic modalities. Major responsibilities include planning, conducting, and documenting experiments designed to investigate metabolic pathways and structural elucidation of metabolites formed from new drug candidates.

Essential Skills/Experience

• Proven ability of metabolite characterization using high resolution mass spectrometry and state-of-the-art metabolite acquisition and processing software

• PhD or equivalent degree in relevant discipline (Biotransformation, Medicinal Chemistry, Organic Chemistry or Analytical Chemistry)

• Knowledge of biotransformation

• Good understanding of in vitro and in vivo approaches used to understand drug metabolism issues

• Ability to work independently and problem solve with an extensive track record of generating high quality data and reports

• Scientific leadership, evidenced by a publication track record

• Good communication skills in English, both verbal and in writing

The successful candidate is adaptable, highly motivated, and challenge-driven with a history that demonstrates strong interpersonal skills that encourage successful collaborative working relationships.

Desirable Skills/Experience

• Knowledge of guidelines and policies in drug development regarding biotransformation, including MIST

• Experience from industry environment

If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then apply now!

Welcome with your application no later than March 23rd 2025.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.