Scientist, Biologics Production

Scientist, Biologics Production

Are you ready to be part of a dynamic team that is revolutionizing biologics production? We are building a high-throughput, automation-first engine to deliver complex biologics—including IgGs and multispecifics—faster, at higher quality, and at scale. As a Scientist in Biologics Production, you will play a crucial role within an integrated team that spans mammalian expression, purification, and fit-for-purpose analytics. Your mission? To compress DNA-to-material timelines for discovery programs and technology development. If you have the drive to innovate, a collaborative mindset, and the ability to communicate and deliver molecules and corresponding data packages, this is the opportunity for you!

Accountabilities:

Production & Process Development

• Aid and execute in improving the sequence-to-material pipeline: transient CHO/HEK expression, purification, and QC assessment of IgGs, VHH (+/- Fc), and multispecifics using high-throughput workflows.
• Predictive analytical QC routes to inform purification groups and meet therapy area demand for decision-quality materials and technology development initiatives.

Purification Automation, Analytics & Digital Operations

• Automated liquid-handling workflows in relation to biologics purification (monospecific and multispecific) and analytical stations (SEC-HPLC or UPLC, CE-SDS).
• Embed data integrity and compliance across workflows via Genedata Biologics, eLN, and Smartsheet governance and training.
• Maintain in-process controls and release-for-use criteria in partnership with Analytics and Developability, including SEC, CE-SDS, Endotoxin, and HCP.

Cross-Functional Impact

• Partner closely with Protein Engineering and Novel Modalities (PENM), Assays/Profiling and Pharmacology (APP), and PS&A Analytics and Developability, and collaborate with BPD Purification Process Sciences for scale-up readiness.

Essential Skills/Experience:

• B.S. in Biochemistry, Bio/Chemical Engineering, or closely related field.
• 2-4 or more years in biologics production and purification in biotech or pharma.
• Experience in mammalian expression and purification/QC (transient CHO or HEK-derived).
• Digital and compliance acumen with Genedata Biologics and eLN or Smartsheet-based governance.

Desirable Skills/Experience:

• Hands-on experience in industry setting with Hamilton liquid-handling platforms for protein purification and normalization.
• Coordination and planning of liquid handler usage and routine operation.
• Experience with Unchained Labs instruments for UV/Vis as well as sample data management and transfer into liquid handling platforms.
• Programming knowledge is a plus for this position.

At AstraZeneca, we are driven by a shared vision to eliminate cancer as a cause of death. Our pioneering spirit fuels bold moves that transform the way cancer is treated, truly improving patient outcomes. With one of the broadest Oncology pipelines in the industry, we offer countless opportunities to work with novel drugs and discover what's next. Our collaborative environment empowers you to take smart risks, challenge norms, and learn from failures. Join us in applying science to studies using innovative approaches that shape the future of Oncology.

Ready to make an impact? Apply now to join our team!

The annual base pay (or hourly rate of compensation) for this position ranges from $80,653.60 - 120,980.40 USD. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

09-Oct-2025

Closing Date

14-Nov-2025

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.