Clinical Scientist, Early Clinical Development, CVRM

In Cardiovascular, Renal & Metabolism, we are investigating the drivers of CVRM disease progression through ground breaking scientific methods and data-driven drug discovery and development approaches. In this context, the Translational Science and Clinical Development team are investigating a wide range of different drug modalities from a rich CVRM portfolio across cardiovascular, kidney and metabolic disease patient populations.

We are looking for an experienced scientist with clinical and/or translational research experience in cardiovascular, metabolic and/or kidney disease to join us. Your ambition to improving patients’ lives will involve you in a team working in a multidisciplinary environment, driving the translational and clinical development of novel innovative therapies in CVRM diseases. In this role, you will have the opportunity to work at the forefront of early clinical and translational research.

What you’ll do

As a clinical and translational scientist, your core accountability will be scientific support for the scientific development and execution of project clinical strategies based upon your established expertise including the latest thinking about mechanisms of disease, diagnostic approaches, current treatment options, drug development trends, and regulatory requirements in relevant disease and therapeutic areas. You will contribute to pre-clinical and early phase clinical trials and related clinical research projects for potential therapies that are targeting cardiovascular, renal and metabolic diseases, as well as serving as an expert on the translational human target validation, clinical design, document generation, conduct, monitoring, data interpretation, and reporting of these studies. Additional tasks include supporting regulatory documentation, liaison with discovery scientists, regulatory, clinical and commercial colleagues, developing and managing external collaborations, and developing a deep knowledge of the literature pertaining to the products under development. You will also work on cross-functional teams within our early clinical development group and across the broader early CVRM organization that are framing our strategies and development plans for potential therapies that are targeting major metabolic disorders, given that these disorders intersect with cardiovascular and kidney diseases and influence disease progression. 

Basic Qualifications

• Ph.D with minimum of 5 years of experience in clinical or translational research in cardiovascular, metabolic, or kidney disease
• Experience in biomarker evaluation, human target validation, or translational science knowledge
• Proven experience in writing clinical synopsis/protocols, regulatory materials and clinical study supporting documents
• Experience in assisting in the design and execution of clinical studies as well as researching patient characteristics, treatments and care
• Demonstratable clinical scientific knowledge in either cardiovascular, metabolism and/or kidney disease
• Good publication track record
• Track record of strong delivery focus, excellent communication skills and ability to collaborate successfully on global cross-disciplinary teams

Preferred Qualifications

• Advanced Masters or doctoral degrees
• Experience working in an early clinical trial/research setting within the pharmaceutical industry including preparation of documents supporting clinical trials.

The annual base salary for this position ranges from $185,606 - $278,409. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity and eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.  

Location: Gaithersburg, MD

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Date Posted

13-Oct-2025

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.