Principal Scientist of Genomic Medicine

Are you ready to make a significant impact in the field of genomic medicine?

As a Principal Scientist in the Genomic Medicine Department at Alexion – AstraZeneca Rare Disease, you will be at the forefront of developing groundbreaking therapies for genetic cardiomyopathies. Your expertise in cardiac biology and non-clinical development will drive programs from early discovery through IND-enabling studies. Collaborate with internal teams, external partners, and key opinion leaders to lead cross-functional efforts and push the boundaries of scientific innovation!

Accountabilities:

• Lead programs targeting genetic cardiomyopathies from discovery through preclinical development and IND submission.
• Identify and validate novel therapeutic targets; design and optimize therapeutic strategies.
• Design, implement, and coordinate in vitro and in vivo studies to evaluate efficacy and safety of therapeutic candidates.
• Collaborate cross-functionally with pharmacology, toxicology, CMC, and translational science teams to align on non-clinical development strategies.
• Manage external partnerships with academic institutions, CROs, and KOLs.
• Provide scientific leadership and mentorship to junior scientists and team members.
• Present data and program updates to internal leadership and external collaborators.
• Support regulatory filings, publications, and scientific conference presentations.

Essential Skills/Experience:

• PhD in Molecular Biology, Genetics, Cardiovascular Biology, or a related field.
• Minimum of 5 years industry experience with deep expertise in cardiovascular biology and/or rare genetic diseases, particularly cardiomyopathies.
• Proven track record in precision medicine research and development, with a focus on AAV, LNP, or gene editing technologies.
• Proven scientific excellence through high-impact peer-reviewed publications and presentations at major scientific conferences.
• Outstanding communication and interpersonal skills, with the ability to collaborate effectively across multidisciplinary teams.

Desirable Skills/Experience:

• Knowledge of PK/PD modeling and bioinformatics approaches in therapeutic development.
• Familiarity with regulatory requirements and experience with the IND-enabling process.
• Understanding of cardiac biomarker development to support pharmacodynamic and translational assessments.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we are driven by a passion for innovation and a commitment to making a difference in the lives of patients. Our unique culture fosters collaboration and creativity, allowing you to grow and thrive in an environment where your ideas are valued. With a rapidly expanding portfolio and an entrepreneurial spirit, you'll have the autonomy to explore new ideas while being supported by exceptional leaders and peers. Our dedication to understanding patients' journeys ensures that your work is meaningful and impactful.

Ready to take the next step in your career? Apply now to join our team and be part of something extraordinary!

Date Posted

15-Jul-2025

Closing Date

29-Sep-2025Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation, please contact accommodations@Alexion.com. Alexion participates in E-Verify.