Senior Director, Biostatistics

This Senior Director, Biostatistics role leads a global team of statisticians to shape the design, delivery and interpretation of clinical programs, internal governance decisions and regulatory submissions. The work focuses on bringing rigorous statistical thinking to rare disease drug development, from early strategy through to reimbursement and commercialisation. How will your expertise in biostatistics influence the next generation of life-changing medicines?

You willbe responsible for: 

• Lead, manage and develop a group ofstatisticians

• Leadership to biostatistics staff world-wide 

• Ensures drug projects are successfully delivered by leading biostatistics support and strategy. This includes Development Plans, Regulatory Strategy and Submissions, high level internal governance committees, Health Technology Assessment and Reimbursement/Payerand Commercial support asappropriate forthe stage of the product. 

• Leadership to staff on the product world-wide so that all work is carried out with regards to Alexion standards and external regulations 

• Develop contacts with international and external opinion leaders, consultants, and collaborativegroups

• Provide leadership and direction to improvement projects/activities/initiatives

• Identify & drive the development &utilizationof leading-edge statisticalmethodology, skills, capabilities, tools, processes & best practice,in order toadd value to drugdevelopment

• Lead biostatistics resourcing to deliver projects and input on internal vs outsourcingdelivery

• Maintain understanding and awareness of, as well asinvestigate and implement, new methodologies, therapyareaand developmentadvances

• MayrepresentAlexion and biostatistics to Health Authorities and Reimbursement/Payer Organizations orhigh levelinternal governance committees for specific projects/indications 

• Competent program and project leadership

• Work according to agreed functional andregional Safety, Health, and Environment (SHE) strategyby ensuring proper managementof SHE risks, incidents, reporting,follow-upandimprovements

You will need to have:

• MSc/PhD in Statistics, Mathematics (containingasubstantialstatisticalcomponent), or recognized equivalent tostatsMSc

• Track recordof background in leading independently

• In depth knowledge of technical/regulatory requirements with 10 years experience in pharm/healthcare

• Exemplary technical skills

• Excellent communication skills and ability to build strongrelationships

• Flexible, well-organized, andpossessthe ability to work well underpressure

• Duties of this role aregenerally conductedin an office environment. As is typical of an office-based role, employees must be able, with or without an accommodationto:use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

We would prefer for you to have:

• PhD in Statistics/Biostatisticsispreferred.

• Managerial experience

• Excellent collaborationrequired– needs the energy to work across global & functional boundaries both internally andexternally

• Vision – keen awareness of R&D prioritiesin order toapply novel solutions to scientificproblems

• Travel – willingness to travel domestically &internationally

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our outstanding and ambitious world.

The annual base pay (or hourly rate of compensation) for this position ranges from $221,036.00 - $331,554.00 USD . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

At AstraZeneca’s Rare Disease unit, work is driven by the lived experiences of people with rare and devastating conditions, keeping patients at the centre of every decision. Teams combine the agility of a biotech with the reach of a global biopharmaceutical company. They build space to experiment, learn quickly, and apply innovative science where unmet needs are high. Colleagues collaborate across disciplines and geographies, supported by leaders who invest in development and encourage speaking up, curiosity and new ideas. Every project offers the chance to turn rigorous science into meaningful change for individuals, their families and their communities.

If this opportunity resonates and your expertise matches what we are looking for, apply now to explore the next step in your career with us.