Medical Healthcare Transformation Manager – Amyloidosis

Are you ready to think and act fast to change the lives of patients living with amyloidosis, a complex disease area with significant impact on polyneuropathy and cardiomyopathy? As a Medical Healthcare Transformation Manager, you will provide medical input to business strategic and operational planning for this new and exciting area of our portfolio. This includes the development of Medical Affairs plans and embedding clinical insight, customer focus, and robust clinical governance into Medical and Business Unitobjectives. You will also contribute to the development of pre-launch and post-launch medical plans, collaborating with AZ cross-functional teams, external experts, and healthcare stakeholders to advance diagnosis, care pathways, and outcomes in amyloidosis-related neuropathic and cardiac involvement.

Accountabilities

• Scientific leadership and partnerships: Identify and partner with national and regional/local Key External Experts (KEEs), healthcare stakeholders and patient advocacy groups (PAGs); maintain up‑to‑date knowledge of the therapeutic landscape, products and competitors.
• Data dissemination and education: Share fair‑balanced, objective scientific information; develop publications and slide decks; facilitate continuing medical education events; respond to unsolicited medical requests in a non‑promotional, substantiated manner.
• Medical strategy and planning: Define early medical plans that guide long‑term strategy for amyloidosis assets; contribute to pre‑ and post‑launch medical plans; bring field insights to shape objectives and tactics.
• Medical value and access: Provide scientific/clinical information to KEEs, payers, managed care organizations and decision makers; support cross‑functional prioritized accounts; contribute to technical access discussions, value propositions and innovative access models; deliver customer insights for Market Access and business planning.
• Cross‑functional brand contribution: Share HCP insights with country, regional and global teams; support pre‑launch activities, monitor competitor actions, and ensure clinical insight informs brand strategy.
• Evidence generation: Participate in design and conduct of local/regional studies and non‑interventional evidence programs, aligned with governance requirements.
• Team leadership and culture: Role‑model AZ Values & Behaviours; develop excellence in execution and field leadership; foster accountability; identify and pursue development plans for self and team.

Essential Skills

• Advanced scientific degree or equivalent experience: MD, PharmD, or PhD in a scientific field.
• Medical Affairs expertise: Prior experience and solid understanding of Medical Affairs, including clinical governance and scientific exchange principles.
• Healthcare ecosystem knowledge: Strong understanding of the Portuguese national healthcare system, payer landscape and access pathways, with a deep knowledge of the Cardiology field.
• Communication excellence: Outstanding presentation, written and verbal skills; ability to convey complex scientific, economic and humanistic concepts to sophisticated audiences.
• Partnership and collaboration: Demonstrated ability to build effective relationships internally and externally, including KEEs, payers and cross‑functional teams.
• Strategy and execution: Proven leadership, strategic thinking, project management and analytical/problem‑solving skills; ability to translate insights into action.
• Health economics exposure: Knowledge in Health Economics, Pharmacoeconomics or Pharmacoepidemiology.
• Language proficiency: Fluent Portuguese and advanced English.

Desirable Skills

• Access expertise: Experience partnering with Market Access on value propositions and innovative payer models.
• Local research experience: Exposure to non‑interventional studies and real‑world evidence programs.
• Congress engagement: Ability to capture and share scientific congress highlights and insights across teams.
• Competitor monitoring: Track record of monitoring and interpreting competitor activities to inform strategy.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Here you’ll work where science and real-world impact meet—partnering across discovery, development, access, and field medical to turn evidence into decisions that change practice. You will collaborate with diverse teams, design evidence that answers unmet needs faster, and help steer launches and lifecycle strategies in a setting that values curiosity, clarity, and follow-through. We bring people together to spark bold ideas, move at pace, and support each other to deliver—valuing kindness alongside ambition—so your contribution directly shapes how new therapies reach patients and how healthcare evolves.

Step into this role to shape access and outcomes in amyloidosis—bring your scientific voice and field leadership to create real change today!

Date Posted

11-Feb-2026

Closing Date

24-Feb-2026

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.