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Senior Scientist Chemistry - CB- Chemical Biology

Plats Waltham, Massachusetts, USA Jobb-id R-088863 Datum inlagd 08/18/2020

Senior Scientist Chemistry - CB- Chemical Biology

Waltham, MA

AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. In AstraZeneca Oncology, our goal is to be at the forefront of developing the next generation of cancer therapies.

Job Purpose:

Team player responsible for the design, synthesis and strategies around chemical tools/probes and their application towards target ID, target engagement, and mechanism of action studies. An ideal candidate will have hands-on experience in quantitative proteomics experiments and/or experiences in biological target validation methods.

Key Accountabilities:

The Senior Scientist Chemistry – CB will be accountable for specified aspects of the chemical biology strategies according to the project objectives that include:

  • The applicant will be responsible for the design and synthesis of small molecules probes   
  • The applicant will experimentally design and perform proteomics-based photocrosslinking pulldowns, chemoproteomics and global proteomics to identify molecular targets and pathways as key drivers in respiratory and oncology disease relevant cell lines
    • Experience with different crosslinking moieties (benzophenone, diazirine) a plus 
  • The applicant will perform additional target engagement techniques (i.e. CETSA) to orthogonally confirm the binding interaction in cells  
  • The ideal candidate will also be responsible for the validation of the identified targets through genetic means (i.e. siRNA or CRISPR) to demonstrate recapitulation of the phenotype.

  • The applicant must be able to work collaboratively as a member of cross-functional teams through regular attendance of project team meetings, presentation of their data and contribute to the overall success of the project.
  • Contribute to publication strategy as needed, driving timely preparation and delivery of patents/research publications in collaboration with IP group.
  • To evaluate and manage relations with external collaborations when and as needed.
  • Scope and internalize new methods for target identification and mechanistic studies.
  • Ensure compliance with corporate policies including GLS and SHE. 

Functional Knowledge

Will require at minimum: PhD in chemical biology or chemistry with postdoctoral experience (0-3yrs.) in chemical biology, or similar disciplines. Will have the ability to operate effectively in multidisciplinary matrix research environment, providing leadership and insight in their discipline. This role demands significant experience of interacting with people and groups both internal and external.

The ideal candidate should:

  • Be familiar with chemical biology principles and technologies, and their application to small molecule target identification, engagement and validation.
  • Independently design and execute target identification and validation experiments for cellular signaling pathway interrogation, hypothesis testing and practical knowledge with suitable biological models and positive and negative small molecule controls.
  • Should be versed in numerous small molecule bio-orthogonal conjugation approaches applicable to in-lysate and live cell chemical pull-down experiments.
  • Familiarity with bottom-up mass spectrometry-based applications for in cell and in-vitro quantitative proteomics.
  • Preferably have an understanding of cell biology and biochemistry techniques, such as cell lysing, protein extraction and identification.
  • Be active in Chemical Biology forums and publication record in the field (communications to symposiums, peer reviewed journal articles and/or patent applications).

Areas of expertise/specialization

  • Experience and track record in chemical biology and synthetic chemistry.
  • Awareness of recent development in literature in the field of chemical biology as well as synthetic & medicinal chemistry both inside and outside AstraZeneca.
  • Good communication and networking skills.

Leadership capabilities: level 2 or greater

The ideal candidate should:

  • Be familiar with chemical biology principles and technologies, and their application to small molecule target identification, engagement and validation.
  • Independently design and execute target identification and validation experiments for cellular signaling pathway interrogation, hypothesis testing and practical knowledge with suitable biological models and positive and negative small molecule controls.
  • Should be versed in numerous small molecule bio-orthogonal conjugation approaches applicable to in-lysate and live cell chemical pull-down experiments.
  • Familiarity with bottom-up mass spectrometry-based applications for in cell and in-vitro quantitative proteomics.
  • Preferably have an understanding of cell biology and biochemistry techniques, such as cell lysing, protein extraction and identification.
  • Be active in Chemical Biology forums and publication record in the field (communications to symposiums, peer reviewed journal articles and/or patent applications).

Areas of expertise/specialization

  • Experience and track record in chemical biology and synthetic chemistry.
  • Awareness of recent development in literature in the field of chemical biology as well as synthetic & medicinal chemistry both inside and outside AstraZeneca.
  • Good communication and networking skills.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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