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In Vivo Scientist Hematology Oncology Team

Plats Waltham, Massachusetts, USA Jobb-id R-087891 Datum inlagd 07/31/2020

In Vivo Scientist Hematology Oncology Team

At AstraZeneca Oncology, we are not afraid to do things differently. Our vision is redefining cancer, redefining our solutions to cancer and restoring patients' lives.  In this role, you will join a dynamic and collaborative in vivo biology team in our state-of-the-art Biohub facility in Waltham, MA.  The primary responsibility of this position is to build in vivo animal models and conduct PKPD, and efficacy studies to support our oncology R&D portfolio, with a focus on drugs targeting hematologic cancers. 

Key Responsibilities:

  • Use in vivo technical skills to support our hematology oncology platform by:
    • Developing and working with various in vivo models of cancer including subcutaneous xenograft models, disseminated models, PDX models, humanized models, and metastatic models.
    • Conducting in vivo pharmacology studies (tolerability, PKPD, and efficacy) and delivering comprehensive in vivo pharmacology data packages to support early and late stage drug discovery programs.
    • Profiling of tissue samples to explore mechanisms of drug response and resistance using both traditional and novel approaches
  • Demonstrate proficiency and flexibility in working with various programs and databases to capture all study data for broad access by project teams and stakeholders.
  • Work collaboratively across disciplines to develop and implement aggressive work plans and timelines
  • Bring in new technologies and approaches to improve or replace existing disease model platforms that better predict clinical response

Essential requirements:

  • BS or MS in biology, pharmacology, or related field with a minimum of 2 years “hands-on” in vivo experience with proficiency in dosing Sub-Q, PO IV routes, preferably in biopharma.
  • Demonstrated experience generating and working with various rodent disease models.
  • Ability to work both independently as well as within project teams and across disciplines
  • Ability to lead from the bench in problem solving and in the development of innovative solutions
  • Excellent communication and organizational skills
  • Proficiency MS Office Suite, GraphPad PRISM and BioELN.  

Additional experience desired:

  • Experience working with disseminated hematologic cancer models including PDX.
  • Ability to analyze biomarkers in blood and tissue samples using techniques such as flow cytometry and Western blots
  • Experience using small animal imaging modalities

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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