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Senior Scientist or Associate Principal Scientist

Plats South San Francisco, Kalifornien, USA Jobb-id R-062883 Datum inlagd 10/09/2019

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.  We lead our industry in our development of a strong and varied pipeline. This means our people are here to win, we give you a breadth of opportunities to be curious and do cutting edge, unique work that has big impact on science and medicine.

Position Summary:

Senior Scientist / Associate Principal Scientist

The GxP new modality group, within the Clinical Pharmacology and Quantitative Pharmacology Department, is responsible for GxP bioanalysis for diverse modalities and biomarker in support of AstraZeneca post-CD pipeline across TAs. 

The group is seeking a highly motivated Scientist with molecular biology and neutralizing antibody (Nab) assay development experience to conduct bioanalysis in support of preclinical and clinical studies. The successful candidate will be based in South San Francisco and will lead the development, validation and bioanalysis for molecular therapeutics. Other responsibilities include design and execution of Nab and pharmacodynamic biomarker assays to support drug development across multiple therapeutic areas.

The position will be based in South San Francisco, CA.

Major Duties and Responsibilities:

  • Serve as a bioanalytical function lead at cross-functional project teams
  • Lead the design and execution of pharmacodynamic biomarker strategy for preclinical and clinical studies using molecular approaches
  • Oversee the development, validation and bioanalysis of pre-clinical or clinical samples for the determination of oligonucleotide drug modalities
  • Develop and validate Nab assays for biologic molecules across multiple therapeutic areas
  • Supervise staff and prioritize resources to provide support for multiple projects
  • Present results at internal and external meetings

Requirements/Qualifications:

Senior Scientist experience:

  • PhD in biological sciences or related field
  • >3 years of experience required
  • Strong expertise in molecular biology and assay development
  • Knowledge in drug development
  • Demonstrated ability for scientific insight and conceptual thinking in development of strategic drug development programs
  • Experiences in method development for molecular-based pharmacodynamic biomarkers and/or drug concentration for oligonucleotide drug modalities supporting preclinical and clinical studies
  • Experience in Nab assay development to support clinical development
  • Excellent interpersonal, organization and communication skills
  • Ability to work in a team environment and to deliver on multiple projects simultaneously
  • Proficiency with spreadsheet, word processing, and graphical computer programs (MS EXCEL, MS WORD, Graphpad Prism, for example) required

Associate Principal Scientist experience:

  • PhD in biological sciences or related field
  • >7 years of experience required
  • Strong expertise in molecular biology and assay development
  • Knowledge in drug development
  • Demonstrated ability for scientific insight and conceptual thinking in development of strategic drug development programs
  • Experiences in method development for molecular-based pharmacodynamic biomarkers and/or drug concentration for oligonucleotide drug modalities supporting preclinical and clinical studies
  • Experience in Nab assay development to support clinical development
  • Excellent interpersonal, organization and communication skills
  • Ability to work in a team environment and to deliver on multiple projects simultaneously
  • Proficiency with spreadsheet, word processing, and graphical computer programs (MS EXCEL, MS WORD, Graphpad Prism, for example) require

Desired:

  • Familiarity with assay validation guidelines and GLP regulations is a plus
  • Management experience to independently manage a team of scientists is preferred

#molecularbiology

#Nab

#assaydevelopment

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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