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Senior Scientist, Cell Therapy (Stem Cells)

Plats Gaithersburg, Maryland, USA Jobb-id R-142292 Datum inlagd 06/30/2022

Senior Scientist, Cell Therapy (Stem Cells)

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the place for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most groundbreaking technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while growing collaboration between teams.

Summary of the group:

The Cell Culture and Fermentation Sciences Group is accountable for cell line development, process development, and process characterization. This group assists in the scale up and technical transfer of processes to different clinical and commercial sites and also supports manufacturing deviations and regulatory submissions as needed.

Main Duties & Responsibilities:

This position within the Cell Culture and Fermentation Sciences group would involve performing experiments to design, optimize, characterize, and scale up stem cell culture processes. The candidate will be involved in developing a manufacturing ready cell culture platform that can be scaled up consistently across scales. The work will involve performing cloning/subcloning processes for stem cells and evaluating/developing bioreactor platforms as well as different media for growing stem cells. Finally, the work will involve understanding how different nutritional, mechanical, and hydrodynamic parameters may affect stem cell fate. The candidate is expected to have sound knowledge of stem cell biology and genome engineering approaches and apply the relevant techniques as needed for intended applications. The following is desired of the candidate:

  • Applies molecular/bioreactor engineering principles to advance the stem cell upstream platform

  • Performs laboratory experiments using ESCs/iPSCs through cross functional interactions to advance the pipeline and understand the fundamental mechanisms associated with stem cell differentiation, shear sensitivity, stress response, or/and scale-up of stem cells

  • Makes detailed observations, analyses data, and interprets results. Demonstrates scientific rigor in assessing own data and that of others and utilizes forward-looking perspective to contribute to “go/no-go” decisions

  • Familiar with different analytical methods that are used to characterize different stages in stem cell proliferation and differentiation

  • Strategic thinker, evolving subject matter expert in stem cell field, strong publication record, leads/participates in various cross functional technology development teams

  • Authors and contributes to development reports, scientific publications, patents, and regulatory submissions

Education & Experience Requirements:

Education: Bachelor’s, Master’s, or PhD in Chemical/Biochemical/Biomedical Engineering, Biotechnology, Biochemistry, Cell Biology, Immunology, Biological Sciences or related field

Experience: BS and 10+ years, MS and 8+ years, or PhD and 0+ years of relevant experience

Required Skills:

  • Strong background in stem cell bioprocessing or biology, applies molecular/bioreactor engineering principles to advance the stem cell upstream platform

  • Excellent teamwork and communication skills including proven technical writing skills, good publication record, and effectively presents results at internal meetings and external scientific meetings.

  • A strong team player who can effectively perform the technical transfer activities and manufacturing support for the clinical/commercial process

  • Works effectively and collegially as a team member within a highly matrixed organizational structure

  • Is knowledgeable in either or all the of the following areas: stem cell bioprocessing, stem cell biology, hypoimmunogenicity, kill switches, or genetic manipulation of stem cells.

Desired Skills:

  • Experience with stem cell engineering or process development

  • Expertise in one of key scientific areas such as stem cell bioprocessing or stem cell genomics/gene editing

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

Check out our landing page for more information on our BPD group

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AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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