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Scientist Bioscience Immunology, Early Respiratory and Immunology

Plats Gaithersburg, Maryland, USA Jobb-id R-092468 Datum inlagd 10/31/2020

Scientist Bioscience Immunology, Early Respiratory and Immunology

Are you an experienced Scientist ready to apply your skills in an and company? Do you want a breadth of opportunities to be curious and do groundbreaking, outstanding work that has a big impact on science and medicine? If you can envision providing scientific expertise in a role that can impact patients’ lives – join us today!

Early R&I is one of three research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. As a part of building the Immunology Bioscience team within the Early R&I department, we are seeking a highly motivated Scientist with a strong understanding of adaptive and/or innate immunity and ideally understanding key biological pathways in immune-mediated diseases such as rheumatological and/or diseases. The role will be based at our vibrant R&D site in Gaithersburg (US) within AstraZeneca’s laboratories.

At AstraZeneca Respiratory & Immunology, we’re driven by innovation and our dedication to making a real-life difference in patients’ lives. That difference starts with you.

What you’ll do

In this role, you would be encouraged to demonstrate an outstandingly high level of passion for innovative scientific research leading to the discovery and development of novel therapeutics. Ideally, you have expertise with innate and adaptive immune cell assays and an understanding of the pathogenic mechanisms involved in immune-mediated diseases. Experience in sophisticated co-culture systems and cell imaging, and an ability to apply this experience to an understanding of the basic mechanisms of human immune-mediated disease is preferred.

This job is a lab-based research role, and you will have a significant opportunity to drive the direction of the work. The work will be predominantly with human in vitro systems, working with primary and disease tissue-derived cells, although evaluation in vivo pharmacology and experimental mechanistic and disease models will be vital. A background in human immunology and immune-mediated diseases and translational approaches to understand basic biological mechanisms in disease is needed.

Example of accountabilities:

  • You will focus your research on characterizing novel immunological pathways in health and disease to aid target validation and drug projects
  • You will plan and execute drug discovery research experiments independently by applying molecular and cellular biology techniques, and to interpret and communicate results to team members
  • You will supply to the development of the strategies for new target identification and validation
  • You will collaborate with scientists from a variety of functional teams in Gaithersburg and with our sites in Cambridge, UK, and Gothenburg, Sweden.
  • You will be involved in the development of new assays and implementing novel technical advances with human tissue cultures
  • Publication of your work in high impact journals.

Essential for the role

A Master's or Bachelor’s degree in immunology or relevant field.

You are highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team to conduct a high-level research project

Additionally, you possess:

  • Strong hands-on skills in basic biochemical and molecular techniques including cell culture, quantification of mRNA (qPCR) and protein expression; ELISA, Western blot, Immunoprecipitation, assay development, and over-expression, knock-down, and knock-out techniques.
  • Expertise in primary human cell culture including co-culture models, expertise in multi-panel FACS, including both intracellular and extracellular cell surface markers is crucial.
  • Strong written and oral communication skills and the ability to critically analyze datasets. Proven track record to run collaborative efforts and utilize external resources to find the most effective solutions to drug discovery problems

Desirable for the role

  • Expertise in drug discovery projects in immunology or a closely related field of biology is preferred
  • In vivo skills are a strong plus particularly models of inflammation and autoimmunity

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being results-oriented -finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, groundbreaking cutting edge methods, and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you already conceptualizing yourself joining our team? Good, because we can’t wait to hear from you.

Where can I find out more?

  • Follow AstraZeneca on LinkedIn
  • Follow AstraZeneca on Facebook
  • Follow AstraZeneca on Instagram

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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