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R&D Associate II / Associate Scientist I, Protein and Viral Vector Purification

Plats Gaithersburg, Maryland, USA Jobb-id R-092464 Datum inlagd 10/31/2020

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration through scientific research. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity.

Job Description

Position is a hands-on, laboratory-based role.

The successful candidate will:

  • Develop and characterize purification processes for the manufacture of biopharmaceuticals (viral vectors, antibodies and other proteins) in early stage clinical development.
  • Be responsible for a portion of a purification process development project.
  • Make observations, analyze data and interpret results.
  • Maintain accurate records of experimental results, review, analyze, and interpret experimental data.
  • Make periodic presentations in group meetings, project team meetings, and in one-on-one situations.
  • Prepare/review development reports and technology transfer documents.
  • Support technology transfer to Clinical Manufacturing facilities.
  • Support troubleshooting and resolution of deviations in GMP manufacturing processes.
  • Evaluate new technologies for purification process development.

Position Requirements

Education:

Bachelor's or Master's Degree in Biochemistry, Biology, Chemical/Biochemical Engineering, Virology or related field.

R&D Associate II: requires a Bachelor's Degree with 2+ years of relevant industrial experience or a Master's Degree with some experience preferred. This role requires at least 1 year of relevant experience in protein and or viral vector purification

Associate Scientist I: requires a Bachelor's Degree with 5+ years of relevant industrial experience or a Master's Degree with 2+ years of relevant industrial experience. This role requires at least 1 year of relevant experience in protein and or viral vector purification

  • Candidate will be required to sign an Acknowledgement, Informed Consent, & Prohibition statement due to the nature of the assigned project, agreeing to, among other things, being prohibited from living with or coming in contact with susceptible avian species.

Essential Skills:

  • At least 1 year of relevant experience in protein and or viral vector purification
  • Proficiency in protein and viral vector purification principles and methods including different modes of chromatography, centrifugation, normal and tangential flow filtration, virus removal and inactivation steps.
  • Knowledge of basic protein and analytical chemistry.
  • Basic analytical techniques for protein and viral vector products (HPLC analysis, protein quantification methods, electrophoresis; Western blotting, etc.).
  • Hands on experience AKTA chromatography systems/software (preferred).
  • Working knowledge of good laboratory practices.
  • Highly team-oriented, energetic, critical thinker, organized, capable of significant multitasking with excellent oral and written communication skills.

Preferred Skills

  • Experience with developing purification processes for viral therapeutics including oncolytic viruses and AAV.
  • Working knowledge of statistical design of experiments (DOE).
  • Experience with process scale-up and technology transfer.
  • Background and training in virology (desirable).



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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