Project Toxicologist - Clinical Pharmacology and Safety Sciences (CPSS)
Are you passionate about working for a global health care company who truly puts patients first, and like to apply your toxicology expertise in a company that is accelerating innovative science and turns ideas into life changing medicines?
AstraZeneca discovers and develops medicines in 4 core areas of Oncology, Respiratory and Immunology (R&I), and Cardiovascular, Renal and Metabolic Disease (CVRM). Oncology Safety, a global department within the Clinical Pharmacology and Safety Sciences (CPSS) function, is looking to recruit experienced Project Toxicologists to join their teams to develop and advance our portfolio of innovative anti-cancer medicines in Oncology R&D.
As a Project Toxicologist at AstraZeneca you will work at the forefront of toxicology and safety science, working in a multidisciplinary environment where you will play a key role in progressing a rich and diverse pipeline of immuno-oncology and tumor-targeted therapies that employ novel modalities including cutting-edge mAb-based therapeutics, cell therapies such as CAR-T, next generation viral therapies. Specifically, we are seeking expertise to support the discovery and development of our innovative antibody-drug conjugate (ADC) portfolio. You will combine your experience in toxicology and drug development with strong communication and interpersonal skills to communicate across all levels of internal and external stakeholders.
CPSS is a diverse international department with Project Toxicologists based at several AstraZeneca sites (Gaithersburg and Boston [US] and Cambridge [UK]). For this recruitment, the focus is to bring experienced Project Toxicologists into our organization with flexibility as to location.
As a Project Toxicologist, your main responsibilities will involve:
- Designing, interpreting and delivering toxicology research programs to enable, ADC platform-level safety, candidate drug selection and clinical development.
- Delivering quality nonclinical summaries and other high-level regulatory documents for internal decision bodies and external health authorities.
- Leading the toxicology input to AstraZeneca project teams and interacting with external health authorities. You will operate across international boundaries within CPSS and across R&D functions in AstraZeneca to lead and manage projects and stakeholders.
- Exploring safety risks and developing risk mitigation strategies to advance novel ADC platform technologies and ADC projects with further opportunity to contribute to other modalities such as CAR-T, immuno-oncology and viral therapy safety.
- Providing specialist nonclinical expertise for evaluation of in-licensing and out-licensing opportunities.
- Contributing to the delivery of the departmental strategy and objectives.
- A PhD in toxicology, pharmacology or a related field is preferred. Applicants with university degree and relevant experience in Toxicology or equivalent life-science subject will be considered.
- Experience working as a Project Toxicologist within a pharmaceutical project environment and with a proven track record of working independently and delivering toxicology risk assessments and problem-solving in drug development.
- Experience with tumor-targeted biologics, immuno-oncology and novel modalities are desirable.
- Strong project leadership skills required to lead and manage the safety assessment contribution to a portfolio of global oncology projects and with an ability to collaborate and operate with sensitivity and flexibility in a matrix project environment
- Willingness to challenge conventional thinking and implement creative ideas balanced with a high regard and understanding for the regulatory framework in which AstraZeneca operates
- A social personality with strong inter-personal skills that contributes to our team culture in which trust, cooperative support, diversity and inclusion enable engaged and motivated colleagues to deliver and develop
- Experience in ADC discovery and/or development.
- Awareness of ADC field of research in regards to distribution, uptake, metabolism and toxicity mechanisms and how this contributes to risk assessment and risk mitigation.
In CPSS we aim to stimulate continued creativity throughout our organization by maintaining a culture in which our people feel valued, energized and rewarded for their ideas and contribution to our success. And we support and encourage our people in discovering their own potential, through excellent learning and development opportunities that are available to them throughout their careers. The PT role offers many development opportunities working closely with strategic toxicology leaders within Oncology Safety to develop investigative and regulatory toxicology plans. Due to the diverse nature of the AstraZeneca Oncology portfolio, we have opportunities for Project Toxicologists to support a range of modalities across various phases of development. If you are a Project Toxicologist with experience in the development of pharmaceuticals, we would like to hear from you.
If you are a Project Toxicologist with experience in the development of pharmaceuticals we would like to hear from you!
AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It’s our business to support healthy living, not only for our patients, but also for our employees. Our benefits program is flexible enough to meet employees’ varying needs, offers valuable choices, and is highly driven.
Come and join our journey - Apply today!
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.