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Principal Scientist / Associate Director - Immunology & Cell Biology

Plats Gaithersburg, Maryland, USA Jobb-id R-101111 Datum inlagd 02/23/2021

Principal Scientist / Associate Director - Immunology & Cell Biology

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe!

We are seeking a highly skilled and motivated Ph.D. Scientist with strong immunology and cell biology background to join our Group within Integrated Bioanalysis in Gaithersburg, MD. The position will take a lead role in developing and implementing bioanalytical strategies for advancing our drug pipeline and working as the group representative in multidiscipline drug development teams.


The position is in our Integrated Bioanalysis Department which is part of the Clinical Pharmacology and Quantitative Pharmacology Group, and is responsible for providing high quality, decision-driving data using a variety of platform and novel technologies. Our team primarily focusses on early R&D pre-GLP bioanalyses along with exploratory biomarkers assessments applicable to all therapeutic areas. We have a diverse array of scientists working across many technologies to ensure delivery of critical assays, and data analysis that drive go/no go decisions and ensure the right combination of medicines get to the right patient, in the right dose, and at the right time.

What you'll do

  • Develop and implement bioanalytical strategies to support drug programs (e.g., Oncology, Respiratory and Immunology) from lead candidate selection through clinical trials.

  • Build a platform of in vitro immunogenicity assessment for high risk biologics and new modalities (e.g., CAR-T, T cell engaging antibody circuits) to enable lead selection and assess the potential risk of cytokine release syndrome.  

  • Represent the department on multidiscipline drug development teams, thus ability to support other technologies, especially ligand binding and cell-based functional assays will be a benefit.

  • Supervise associate(s)/scientist(s) and take a lead role in pushing the boundaries in determining lead drug candidates and facilitating global clinical trials.


Essential for the role:

  • Ph.D. in immunology, cell Biology, or other related scientific discipline and post-doctoral experience in related areas.

  • Strong background in immunology, cancer biology and experience with diverse immunologic assays.     

  • 7-10 years of experience in academia or industry coming from projects that developed advanced immune cell function assay development (e.g., human T cell based) and data interpretation skills.

  • A high level of independence and with an ability to develop hypotheses and execute analysis plans for pharmacokinetics, pharmacodynamics and proteomics biomarker data.

  • Attention to details, good communication and collaboration skills. Outstanding record-keeping skills are critical for success.

  • An ability to think and act creatively- independently, and within collaborations.

Desirable for the role

  • Experience with molecular techniques and applications for genome sequencing, qPCR, qRT-PCR.  

  • Experience with advanced data analysis tools for analyzing and visualizing biomarker data (highly valued).

  • Experience with broader Immunoassays e.g. ELISA, multiplex assays, Elispots etc.

  • Knowledge of GxP regulations.

This position is located in Gaithersburg, MD.


The AstraZeneca Gaithersburg campus employs more than 3,500 specialists in our field and is only a short drive from Washington, DC. This green, sustainable, modern, vibrant scientific campus is where we host some of the most cutting-edge technology and lab spaces. Newly designed, state of the art research spaces and open seating floor plans are just a couple of ways we work cross functionally and collaboratively.

The Gaithersburg campus also provides an award winning café, free garage parking with electric car charging stations, bike racks, free fitness center to include classed and personal training game rooms, outdoor patio, bocce ball court, arcade games and game tables, recharge Pod’s, library, walking trails, onsite dry cleaning pickup, haircutting service, health and wellness center, starbucks café, and much more!

Benefits:

AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It’s our business to support healthy living, not only for our patients, but also for our employees. Our benefits program is flexible enough to meet employees’ varying needs, and offers valuable choices.

Are you already imagining yourself joining our team? Apply today!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.

Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next?

Are you already imagining yourself joining our team?

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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