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Associate Scientist I/II - Bioassay Development

Plats Gaithersburg, Maryland, USA Jobb-id R-101751 Datum inlagd 03/02/2021

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.  This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. 

Summary of the group:

The Bioassay Group develops and delivers fit-for-purpose, robust, and technologically advanced biological assays to progress pipeline products from research to commercial. We support end-to-end biological and bioanalytical characterization of AstraZeneca pipeline assets including mAbs, bispecifics, novel molecules, ADCs, oncolytic viruses and vaccines. We also support regulatory filings from IND to BLA and beyond.

Main Duties & Responsibilities:

  • The candidate will play a key role in the development, optimization and qualification of a wide variety of bioassays to support lot release, stability testing and characterization of therapeutic biologics such as antibodies, fusion proteins, vaccines, gene and cellular therapeutics.
  • The candidate will identify, evaluate and implement cutting-edge technologies to improve the efficiency of in-process, release, and characterization bioactivity testing.
  • The candidate will author and review documents including development reports, SOPs, assay transfer plan/protocols/reports, CMC sections of regulatory filings (IND, IMPD, BLA, etc.), and scientific journal publications.
  • The candidate will work in a team setting and to interface with different research and development departments, and present their work both internally and to external partner organizations

Education & Experience Requirements:

Associate Scientist I:  BS with a minimum of 5+ years relevant experience or MS with a minimum of 2+ years relevant experience

Associate Scientist II: BS with 8+ years of relevant experience or MS with 5+ years of relevant experience

Required Skills:

Candidates must have a thorough understanding of cell culture and hands-on experience with in vitro bioassay techniques and their applications in assessing cellular signaling/phenotyping, receptor binding, cytokine secretion, cell proliferation, cytotoxicity, as well as antibody effector function. They must also have good time management and organizational skills The ability to work in a fast-paced team-centered environment with outstanding multi-tasking skills is a must.

Required Skills:

Candidates must have a thorough understanding of cell culture and hands-on experience with in vitro bioassay techniques and their applications in assessing cellular signaling/phenotyping, receptor binding, cytokine secretion, cell proliferation, cytotoxicity, as well as antibody effector function. They must also have good time management and organizational skills The ability to work in a fast-paced team-centered environment with outstanding multi-tasking skills is a must.

Desired Skills:

Cellular/molecular biology, immunology or virology expertise is preferred. Experience with cell and gene therapy, exogenous expression of cell surface receptor, single cell cloning and transcriptional regulation is a plus. GMP experience is a plus.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

Check out our landing page for more information on our BPD group  https://careers.astrazeneca.com/bpd

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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